A Case of Severe, Refractory Antipsychotic-induced Orthostatic Hypotension.
Author: 1Sahil Gambhir, 2Nicholas Sandersfeld, DO, 2Dale D’Mello, MD
Author Affiliations: 1College of Human Medicine, Michigan State University, East Lansing, MI, USA; 2Department of Psychiatry, College of Human Medicine, Michigan State University, East Lansing, MI
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Corresponding Author: Sahil Gambhir, Gambhir1[at]msu.edu
Key Words: Orthostatic hypotension; antipsychotics; refractory; side effects; schizophrenia; management guidelines.
Abstract: Introduction: Antipsychotics have many adverse effects including orthostatic hypotension. Orthostatic hypotension is ideally treated with non-pharmacological strategies; however, these often fail leading to utilization of pharmacological methods. Currently, there is no agreed upon management or protocol for addressing antipsychotic-induced orthostatic hypotension and research in this area is limited. Patient profile: A 60-year-old man with a long history of schizophrenia who was receiving Haldol† Deconoate 200 mg injections every 4 weeks due to previous non-compliance. He was admitted to the inpatient psychiatric service due to worsening psychosis and suicidal behavior. Intervention: Despite use of medications, the patient was switched to risperidone with a goal of transition to an atypical long-acting injectable. The psychosis improved, but the patient developed orthostatic hypotension. After his medications were held, his blood pressure continued to be grossly abnormal. A number of different tests were completed followed by standard non-pharmacological treatment, which proved unsuccessful. Despite receiving intravenous fluid boluses to maintain his blood pressure, the patient required pharmacological treatment. This included midodrine and fludrocortisones, and concluded with Adderall† as his blood pressure stabilized. Conclusion: This case of a 60-year-old man with antipsychotic-induced orthostatic hypotension elucidates the frustration healthcare professionals and patients face with this common treatment-resistant condition. A treatment algorithm for managing drug-induced orthostatic hypotension is proposed and is a nidus for development of future protocols.
Published on date: September 31, 2014
Senior Editor: Kaitlyn Vitale
Junior Editor:Mike Klinger
Citation: Gambhir S, Sandersfeld N, D’Mello D. A Case of Severe, Refractory Antipsychotic-Induced Orthostatic Hypotension. Medical Student Research Journal. 2014;4(Fall): 15-7.
- Cardiac side effects of psychiatric drugs. Mackin, P. Hum Psychopharmacol, 2008 Jan; 23 (1): 3-14. doi: doi: 10.1002/hug.915
- Stahl, S. Chapter 10. Antipsychotic Agents. In: Stahl’s Essential Psychopharmacology: Neuroscientific Basis and Practical Applications, 3e. New York: Cambridge University Press; 2008.
- Effect of midodrine on chlorpromazine-induced orthostatic hypotension in rabbits: comparison with amezinium, etilefrine, and droxidopa. Kurihara, J; Takata, Y; Suzuki, S; Okubo, Y; Kato, H. Biological Pharmacology Bulletin, 2000 Dec; 23(12):1445-9.
- Evaluation and Management of Orthostatic Hypotension. Lanier, Jeff; Mole, Matt; Clay, Emily. American Family Physicians, 2011 Sept 1; 84(5): 527-536.
- Antipsychotic pharmacotherapy and orthostatic hypotension: identification and management. Gugger, JJ. CNS Drugs, 2011 Aug; 25(8): 659-71
- Freeman R. Chapter 20. Syncope. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson J, Loscalzo J. eds. Harrison’s Principles of Internal Medicine, 18e. New York: McGraw-Hill; 2012.
- Crawford MH. Chapter 16. Syncope. In: Crawford MH. eds. Current Diagnosis & Treatment: Cardiology, 4e. New York: McGraw-Hill; 2014.