Fall 2013 – A Rare Case of Breast Carcinosarcoma with Lymphatic Metastasis

A Rare Case of Breast Carcinosarcoma with Lymphatic Metastasis.
Megan C. Hamre1*, Jennifer M. Eschbacher2, Frances Hahn2, Tilina Hu2
1School of Medicine, Creighton University, Omaha, NE, USA
2St. Joseph’s Hospital and Medical Center, Phoenix, AZ, USA


Full Text Article PDF
*Corresponding Author: Megan C. Hamre; Meganhamre1[at]creighton.edu
Key Words: Breast Cancer; Carcinosarcoma; Clinical Protocols; Treatment Protocols; Lymphatic Metastasis.
Introduction and Patient Profile: Carcinosarcoma of the breast is a rare malignancy composed of two cell lines described as a ductal-type carcinoma with a sarcoma-like component. It is an aggressive neoplasm that is usually larger in size than epithelial breast cancers and characterized by a rapid increase in size. A 32-year-old woman presented with a palpable lump in the left upper outer breast. Imaging findings and an ultrasound-guided biopsy demonstrated a malignant neoplasm with chondroid differentiation. Interventions and Outcomes: The patient underwent a modified radical left breast mastectomy with sentinel node biopsy. Pathology report from the mastectomy demonstrated an infiltrating metaplastic carcinoma (MPC) with positive lymph nodes. Discussion: The most unusual feature of this case is the lymph node positivity, as lymphatic spread is uncommonly associated with carcinosarcoma or any subtype of metaplastic carcinoma of the breast. This case is important because it illustrates the potential future need for treatment guidelines for this uncommon tumor.
Published: September 30, 2013
Senior Editor: Skyler Johnson
Junior Editor: Alex Golec
DOI: Pending
Hamre MC, Eschbacher JM, Hahn F, Hu T. A Rare Case of Breast Carcinosarcoma with Lymphatic Metastasis. Medical Student Research Journal. 2013;3(Fall):9-12.
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Kevin Patterson

Executive Editor
Kevin Charles Patterson is a fourth year medical student at Michigan State University’s College of Human Medicine. He is in his eighth year at MSU after graduating with a B.S. in Human Biology and a B.S. in Microbiology, both in 2010. He is considering a career in internal medicine with a combined scientist training program in residency; after residency, his plans include the possibility of a fellowship and the ultimate goal of practicing academic medicine. Editor Note (2013-14): Kevin graduated, matched, and is a resident in Internal Medicine at Ohio State University Wexner Medical Center.