Winter 2011 – Pregnant Patient Presenting with Syncope and a Medulloblastoma: A Case Report

Pregnant Patient Presenting with Syncope and a Medulloblastoma: A Case Report.

Mark Ishak.

Author Affiliations:
New York College of Osteopathic Medicine of NYIT, Old Westbury, NY, USA
Full Text Article PDF

*Corresponding Author: Mark Ishak, mishak[at]nyit.edu

Key Words: Adult medulloblastoma; pregnant; syncope.
Abstract:
Medulloblastoma is a primary cerebellar tumor seen most commonly in the pediatric population. In adults, it represents about 1% of cancer found in the central nervous system. In adult medulloblastoma, only one third of cases occur in women and even less in pregnant women. This case describes a 34-year-old pregnant woman who presented to the emergency department with the syncope, which was found to be secondary to a medulloblastoma.
Published: June 25, 2011

Senior Editor: Steven Plato

Junior Editor: David Hobbs

DOI: http://dx.doi.org/10.15404/msrj.001.001.winter/02

Citation:
Ishak M. Pregnant Patient Presenting with Syncope and a Medulloblastoma: A Case Report. Medical Student Research Journal. 2011;1(Spring):5-7.

References:
1. Adult medulloblastomas. Holland-Frei cancer medicine. Hamilton, ON: BC Decker; 2003. Available from: http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book_cmed6&part_ A19676. [cited July 2010].

2. Oliver TG, Grasfeder LL, Carroll AL, Kaiser C, Gillingham CL, Lin SM, et al. Transcriptional profiling of the sonic hedgehog response; a critical role for N-myc in proliferation of neuronal precursors. Proc Natl Acad Sci. 2003; 100(12):7331-36. http://dx.doi.org/10.1073/pnas.0832317100.

3. Sasai K, Romer JT, Lee Y, Finkelstein D, Fuller C, McKinnon PJ, et al. Shh pathway is down-regulated in cultured medulloblastoma cells: implications for preclinical studies. Cancer Res. 2006; 66(8): 4215-22. http://dx.doi.org/10.1158/0008-5472.CAN-05-4505.

4. Belcher SM, Ma X, Le HH. Blockade of estrogen receptors signaling inhibits growth and migration of medulloblastoma. Endocrinology. 2009; 150(3):1112-21. http://dx.doi.org/10.1210/en.2008-1363.

5. Pregnancy and Dizziness. 2007. Available from: http://www.americanpregnancy.org/pregnancyhealth/dizziness.html. [cited July 2010].

6. Morag R, Brenner B. Syncope: differential diagnosis & workup. eMedicine 2010. http://emedicine.medscape.com/article/811669-differential. [cited 13 April 2011].

7. Ismail K, Coakham HB, Walters JM. Intracranial meningioma with progesterone positive receptors in late pregnancy. Eur J Anaesthesiol. 1998; 15(1):106-9. http://dx.doi.org/10.1046/j.1365-2346.1998.00225.x.

The following two tabs change content below.

Kevin Patterson

Executive Editor
Kevin Charles Patterson is a fourth year medical student at Michigan State University’s College of Human Medicine. He is in his eighth year at MSU after graduating with a B.S. in Human Biology and a B.S. in Microbiology, both in 2010. He is considering a career in internal medicine with a combined scientist training program in residency; after residency, his plans include the possibility of a fellowship and the ultimate goal of practicing academic medicine. Editor Note (2013-14): Kevin graduated, matched, and is a resident in Internal Medicine at Ohio State University Wexner Medical Center.