Determining if a Relationship Exists Between Tonsillar Ectopia and Symptom Presentation in Chiari Malformation Patients
Author: Julia R. Saling, B.S.1, Paige Marty, B.S.2, Rebecca Fischbein, Ph.D3, Michelle Chyatte, Dr.PH., MPH4
1 Student Research Fellow, Northeast Ohio Medical University
2 Student Research Fellow, Northeast Ohio Medical University
3 Research Coordinator and Assistant Professor of Family and Community Medicine, Northeast Ohio Medical University
4 Assistant Professor of Family and Community Medicine, Northeast Ohio Medical UniversityFull Text Article PDF
Corresponding Author: Julia R. Saling, firstname.lastname@example.org
Key Words: Chiari Malformation Type I, Tonsillar Ectopia, Symptom Presentation
Chiari Malformation Type I (CM I) is characterized by cerebellar tonsil ectopia and has varying symptomatology . Previous research has shown a relationship between tonsillar dominance and related conditions but few examined association with symptomatology. This study attempts to elucidate a relationship between cerebellar tonsil dominance, age, and symptomatology.
Data from CM I patients were extracted from the Conquer Chiari Patient Registry. Tonsillar dominance was determined using a ratio of right-to-left herniation length. Pearson’s correlation and one-tailed Student’s T-test were used for analysis.
Length of tonsillar descent appears to be negatively correlated to age of onset (r = -0.266; p < 0.001; n = 113) and diagnosis (r = -0.323; p < 0.001; n = 113). No correlation was found between tonsillar dominance and symptom location, nor between tonsillar dominance and symptom severity bilaterally (p > 0.05). Symptom location and severity ratios appear to be correlated (r = 0.666; p < 0.001). Tonsillar descent length appears to be strongly correlated bilaterally (r = 0.972; p < 0.001; n = 50).
Inconsistency between tonsillar dominance as related to symptomatology suggests a multifactorial contribution to clinical presentation. The inverse relationship between tonsillar herniation length and age of symptom onset and diagnosis suggests herniation length may be an important predictor for clinical outcomes. Further research is needed to elucidate additional contributing factors and tonsillar dominance and symptomatology association.
Published on date: August, 2016
Citation: Saling et al. Determining if a Relationship Exists Between Tonsillar Ectopia and Symptom Presentation in Chiari Malformation Patients Medical Student Research Journal (2016). doi:10.15404/msrj/08.2016.0007
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Pain Relief and Intervertebral Disc Rehydration Following Wallis® Interspinous Device Implantation: a Case Report.
Author: Carter R. Mohnssen, B.S.1,2, Kenneth Pettine, MD2, and Nicole Rittenhouse, MA, CCRC2
1 Creighton University School of Medicine, Omaha, Nebraska, USA.
2 The Spine Institute, Loveland, Colorado, USA.Full Text Article PDF
Corresponding Author: Carter Mohnssen, CarterMohnssen@creighton.edu
Key Words: intervertebral disc degeneration, case reports, orthopedics, therapeutics, biologics
Introduction: Degeneration of the lumbar motion segment is the primary cause of low back pain in many individuals. Therefore, new minimally invasive treatments are being sought.
Patient Profile: A 47-year old man presented with severe low back pain and radicular symptoms of several years duration. Lumbar MRI revealed severe desiccation, loss of disc height, and an annular tear with right lateral disc protrusion at L4-5.
Interventions/Outcomes: After conservative treatment failed, the patient received a Wallis® interspinous spacer at the affected level. 100% subjective pain relief was obtained at 3 months post-op. Nucleus pulposus rehydration on MRI was observed.
Discussion: Controversy exists over whether disc dehydration is a reliable indicator of low back pain; however, interspinous spacers seem to alter abnormal motion segment’s biomechanics in a way that results in alleviation of low back pain and increased range of motion. With the advent of biologic therapy, this may provide an intriguing minimally invasive treatment modality, although further research is needed.
Published on date: August, 2016
Citation: Mohnssen, C. Pain relief and intervertebral disc rehydration following Wallis interspinous device implantation: a case report. Medical Student Research Journal (2016). doi: 10.15404/msrj/04.2016.0006
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Time to Neurological Deterioration in Ischemic Stroke.
Author: James E. Siegler, MD1†, Karen C. Albright, DO, MPH2,3,4,5†, Alexander J. George, BS1, Amelia K. Boehme, MSPH2, Michael A. Gillette, MPH 1, Andre D. Kumar, MD1, Monica Aswani MSPH6, Sheryl Martin-Schild, MD, PhD1
1 Stroke Program, Department of Neurology, Tulane University Hospital, New Orleans, LA 70112.
2 Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, 35294.
3 Health Services and Outcomes Research Center for Outcome and Effectiveness Research and Education (COERE), University of Alabama at Birmingham, 35294.
4 Center of Excellence in Comparative Effectiveness Research for Eliminating Disparities (CERED) Minority Health & Health Disparities Research Center (MHRC), University of Alabama at Birmingham, 35294.
5 Department of Neurology, School of Medicine, University of Alabama at Birmingham, 35294.
6 Department of Department of Health Care Organization and Policy, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35249.
† Siegler and Albright contributed equally to this article as first authors.Full Text Article PDF
Corresponding Author: Sheryl Martin-Schild, email@example.com
Key Words: Acute ischemic stroke, neurological deterioration, latency, time to event analysis
Background: Neurological deterioration (ND) is common, with nearly one-half of ND patients deteriorating within the first 24 to 48 hours of stroke. The timing of ND with respect to ND etiology and reversibility has not been investigated.
Methods: At our center, we define ND as an increase of 2 or more points in the National Institutes of Health Stroke Scale (NIHSS) score within 24 hours and categorize etiologies of ND according to clinical reversibility. ND etiologies were considered non-reversible if such causes may have produced or extended any areas of ischemic neurologic injury due to temporary or permanent impairment in cerebral perfusion.
Results: Seventy-one of 350 ischemic stroke patients experienced ND. Over half (54.9%) of the patients who experienced ND did so within the 48 hours of last seen normal. The median time to ND for non-reversible causes was 1.5 days (IQR 0.9, 2.4 days) versus 2.6 days for reversible causes (IQR 1.4, 5.5 days, p=0.011). After adjusting for NIHSS and hematocrit on admission, the log-normal survival model demonstrated that for each 1-year increase in a patient’s age, we expect a 3.9% shorter time to ND (p=0.0257). In addition, adjusting for age and hematocrit on admission, we found that that for each 1-point increase in the admission NIHSS, we expect a 3.1% shorter time to ND (p=0.0034).
Conclusions: We found that despite having similar stroke severity and age, patients with nonreversible causes of ND had significantly shorter median time to ND when compared to patients with reversible causes of ND.
Published on date: March, 2016
Citation: Siegler J, Albright K, et al. Time to Neurological Deterioration in Ischemic Stroke. Medical Student Research Journal (2016). doi:10.15404/msrj/03.2016.0005
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Does Traditional Chinese Medicine Matter? Medical Choices of Rural Diabetic Patients in Changsha, China
Author: Xiaoyue Mona Guo, B.A.1, Shuiyuan Xiao, M.D., Ph.D.2
1Yale University School of Medicine, New Haven, CT USA
2Department of Social Medicine and Health Management, School of Public Health, Central South University, Changsha, Hunan, ChinaFull Text Article PDF
Corresponding Author: Xiaoyue Mona Guo
Key Words: Traditional Chinese Medicine, Health-seeking behaviors, Rural China, Diabetes
Introduction: With an aging, urbanizing population, China is home to the world’s largest number of adult diabetics. Although more diabetic patients currently live in cities, the prevalence of pre-diabetes is greater in the rural population due to changing dietary and physical habits, as well as the relative poverty. This demographic is thus an important target for public health intervention. As Traditional Chinese Medicine (TCM) is viewed in China as useful for treating chronic diseases and widely accepted, we sought to explore its use for rural diabetic patients.
Methods: The study population included 63 diabetic patients and two village doctors from four rural villages near Changsha, China. An initial survey was orally conducted with all 63 participants to collect demographics, financial situation, health-seeking behaviors, treatment beliefs, and medical expenditure. Three focus groups of six rural patients each were subsequently held at village health centers. For analysis, questionnaire data was summarized using means and standard deviations or medians and quartiles. Focus group sessions were voice-recorded and transcripts were coded for thematic analysis.
Results/Conclusions: Questionnaire data revealed that for the majority of participants, seeing a doctor is costly in terms of time and money. Patients often do not have the luxury of choosing their medical provider. Despite the benefits of TCM, its slow speed and cumbersome preparation methods do not fit a need for immediate results. Furthermore, TCM doctors are not as available or accessible as Western medicine doctors. As such, although 20% of rural patients rated higher trust in TCM than WM, no patient solely used TCM for their treatment. Instead, almost 40% of patients try to use both TCM and WM. Village practitioners similarly believed that although diabetes treatment should go towards integrative treatment, TCM’s development is hindered by its slow onset and inconvenience coupled with a more systemic lack of TCM infrastructure and research in China. In summary, the continued trust that rural patients place in TCM supports further research for better understanding the true economic, social, and health benefits of having combined TCM-WM treatment be part of diabetes standard of care.
Published on date: March 2016
Citation: Guo X, Xiao S. Does Traditional Chinese Medicine Matter? Medical Choices of Rural Diabetic Patients in Changsha, China, Medical Student Research Journal (2016). doi:10.15404/msrj/03.2016.0004
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Combating Obstacles to Empathy: A Replicable Small Group Discussion Series for Medical Students
Author: Francesca P. Kingery, M.S.1*, Alexander Bajorek, M.D. M.A.2, Amber Zimmer Deptola, M.D.3 Karen Hughes Miller, Ph.D.4, Craig Ziegler Ph.D.5, Pradip D. Patel M.D.6
1School of Medicine, University of Louisville, Louisville, KY, USA.
2Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston MA, USA.
3Washington University School of Medicine, St. Louis, MO, USA.
4Graduate Medical Education, University of Louisville School of Medicine, Louisville, KY, USA.
5Office of Medical Education, University of Louisville School of Medicine, Louisville, KY, USA.
6Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY, USA.Full Text Article PDF
Corresponding Author: Francesca P. Kingery, firstname.lastname@example.org
Key Words: Medical Humanities, Bioethics, Curriculum, Student-led, Empathy, Medical Education, Pre-Clinical
The expression of humanism in patient encounters is a core component of the medical profession and evolving national medical student curriculum. Growing evidence suggests that empathetic care improves patient outcomes and diagnostic accuracy while decreasing physician stress and rates of litigation. Unfortunately, multiple recent studies using different scales and survey tools have consistently shown empathy to decrease during the third and fourth years of medical school. We developed a replicable, case-based, student and expert-driven, small-group discussion series designed to address this decline. Over two years, the series included four separate discussions over controversial topics seldom addressed by formal courses (Chronic Pain Management vs. Prescription Drug Abuse, Balancing Business and Medicine, and Domestic Violence). We utilized pre- and post-session surveys to qualitatively and quantitatively evaluate the program. Our results demonstrated significant improvement in participants’ comfort with the subject matter and desire to approach faculty and peers regarding humanistic patient care. Future and more frequent interactions, combined with optimization of the format could further uncover the utility of this program. Ultimately, we believe our discussion series could be replicated on other medical campuses.
Published on date: March, 2016
Citation: Kingery et al. Combating Obstacles to Empathy: A Replicable Small Group Discussion Series for Medical Students Medical Student Research Journal (2016). doi: 10.15404/msrj/03.2016.0001
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Medals4Mettle: A Program to Enhance the Medical Student-Patient Bond
Author: McKenzie Vater MS31*, Pradip D. Patel MD2, Kanyalakshmi Ayyanar, MD3, Autumn Marks, RN BSN CPHON4, Craig Ziegler, PhD5, Karen Hughes Miller, PhD6
1Medical Student, University of Louisville School of Medicine, Louisville, KY, USA.
2 Professor of Pediatrics, University of Louisville School of Medicine, Louisville, KY, USA.
3 Associate Professor, Division of Pediatric Hematology Oncology, University of Louisville, Louisville, KY, USA.
4Practice Manager, University of Louisville Physicians Pediatric Cancer and Blood Disorders, Louisville, KY, USA.
5 Biostatistician, University of Louisville School of Medicine, Louisville, KY, USA.
6 Associate Professor, University of Louisville School of Medicine, Louisville, KY, USA.Full Text Article PDF
Corresponding Author: McKenzie Vater, email@example.com
Key Words: service learning, humanism, empathy, student/patient communication, extracurricular activity
Introduction: Humanism is a necessary component of patient care. Medical schools are implementing strategies to educate students about humanism in medicine. The University of Louisville School of Medicine (ULSOM) encourages such practices through collaboration with Medals4Mettle (M4M), a non-profit organization that gives marathon medals to patients battling debilitating illnesses. The ULSOM’s chapter matches students participating in the Kentucky Derby Half/Full Marathon with pediatric patients, allowing students to establish a relationship with their “running buddies” prior to gifting their medals on race day as an act of support and acknowledgement of their struggle. The goal of this study was to evaluate the ULSOM chapter and to create a replicable model for other institutions to employ.
Methods: We conducted a survey for current and previous student and patient/parent participants. Participants were asked to complete six 5-point Likert scaled questions anchored with “Strongly Disagree” to “Strongly Agree” and three open-ended questions. The surveys were analyzed using the Mann-Whitney U test for quantitative analysis and Pandit’s variation of Glaser and Straus’ constant comparison for qualitative analysis.
Results: Data was collected from 62 medical students and 21 patients or parents (49% and 33% response rate, respectively). Five of the scaled questions had mean scores above 4.0, revealing that the majority of participants would recommend the M4M program to others and that M4M helped students relate to their patient on a personal level. The qualitative analysis identified four themes among participants: M4M is a wonderful program, it provides a patient benefit, people want to re-participate, and it allows you to connect with others.
Discussion: Findings from the survey suggest the implementation of programs like M4M will promote the integration of humanistic practices into medical school curricula. In the future, we plan to pair medical students with the patients earlier to create a longer-lasting, more meaningful relationship prior to the race.
Published on date: March, 2016
Citation: McKenzie et al. Medals4Mettle: A Program to Enhance the Medical Student-Patient Bond, Medical Student Research Journal (2016). doi: 10.15404/msrj/03.2016.0002
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MSRJ’s Exciting New Feature!
The staff of MSRJ is extremely pleased to announce the addition of an exciting new feature to our journal! Starting today, we will be launching MSRJ e-Publication, which will be our first ever early-access publication issue. MSRJ e-publication will enable us to publish articles “online before print” as many other journals do. This new feature has many advantages for our student contributors including:
- Faster publishing time for accepted manuscripts
- Increased ease of access
- Greater longevity of published literature
- Assignment of a unique Digital Object Identifier number
We want to express our appreciation and thanks to the authors who have been instrumental in getting this put together. We invite you to take a look at their articles in our first-ever e-Pub Early Access Issue:
Combating Obstacles to Empathy: A Replicable Small Group Discussion Series for Medical Students.
Authors: Francesca P. Kingery, M.S., Alexander Bajorek, M.D. M.A., Amber Zimmer Deptola, M.D. Karen Hughes Miller, Ph.D., Craig Ziegler Ph.D., Pradip D. Patel M.D.
Medals4Mettle: A Program to Enhance the Medical Student-Patient Bond
Authors: McKenzie Vater MS3, Pradip D. Patel MD, Kanyalakshmi Ayyanar, MD, Autumn Marks, RN BSN CPHON, Craig Ziegler, PhD, Karen Hughes Miller,PhD
Does Traditional Chinese Medicine Matter? Medical Choices of Rural Diabetic Patients in Changsha, China.
Authors: Xiaoyue Mona Guo, B.A., Shuiyuan Xiao, M.D., Ph.D.
Authors: James E. Siegler, MD; Karen C. Albright, DO, MPH; Alexander J. George, BS; Amelia K. Boehme, MSPH; Michael A. Gillette, MPH; Andre D. Kumar, MD; Monica Aswani MSPH; Sheryl Martin-Schild, MD, PhD
What is e-Publication?
With MSRJ ePubs, not only will student authors be able to see their manuscripts published earlier, but each article will be assigned an individual Digital Object Identifier (DOI) number. A DOI number is a unique alphanumeric string assigned to a digital object. The DOI number is then registered with CrossRef.org, which is an official DOI registration agency dedicated to providing reliable and efficient reference linking for online scholarly material.
Each DOI uniquely identifies the article and provides a permanent link that takes readers to that particular electronic document, even if the web address which originally hosted the article changes.
These DOI’s already exist in various online journals such as JAMA and NEJM. They also provide ease of citation since they provide a short, easy, and unchanging link to the original document as opposed to a lengthy web address.
What Does This Mean for Student Contributors?
The use of DOIs enables us to safely publish intellectual property on the internet, prior to print, and without fear of plagiarism. The fact that DOIs are registered with Crossref © makes them permanent, so our student authors will always be able to find their articles, even many years down the road, using just that unique identifier. Finally, it makes these articles easy to reference, for any future researchers.
At any point in the future, people can access an article just by typing doi.org/ followed by the DOI number. This will automatically take you to wherever the article is housed at that time. It’s that simple!
Starting from today onwards, accepted manuscripts which have been prepared for e-Publication will be available for viewing under the new tab “ePubs” under “Publications” on the MSRJ website. Once we are off the ground, our MSRJ Tech Team will continue to work with the Executive Editors to format and prepare accepted manuscripts for e-Publication, and will continue fine-tuning the process to ensure smooth and continuous e-Publishing.
Behind the Scenes Work:
We would like to extend a special thanks our wonderful MSRJ Tech Team for their endless energy and tireless work towards getting e-Publication launched and helping our journal continue to grow. This has been no small feat, and we could not have done it without them! Leading the charge are Danny Yau and Danielle Levy, second-year medical students at MSU-CHM. They have been instrumental in designing the MSRJ template for our e-Publications, getting the MSRJ set up to accept and publish e-Publications, andestablishing the procedure for assigning DOIs to our manuscripts for future online publication.
We would also like to thank our faculty advisors, Dr. Luz and Dr. Trottier, for their support in helping us coordinate this transition to e-Publication.
As the longest-running journal run by medical students for medical students, we at the MSRJ strive to provide the highest quality product and experience for our student contributors. We hope that the addition of e-Publication will provide medical students another platform to promote their scholarship and research. and would like to thank our authors for their great submissions, support, and patience as we transition into this new phase.
On Wednesday, February 10, Dr. Rajil Karnani came to the East Lansing campus to talk to the students in the MSRJ Elective about careers in academic medicine. He presented about the many ways to become involved in academia, and the variety of career pathways that academic medicine can offer. He covered the advantages and disadvantages to consider, along with the keys to success that he has learned over the years. Dr. Karnani also gave some personal anecdotes on his experience and some tricks of the trade that he wished he knew when he entered the field. Lastly, Dr. Karnani fielded questions from the 30 students who attended the lecture. The students enjoyed the lecture and found it very informative, as careers in academic medicine are seldom talked about during our learning and training.
Introducing the new 2015 – 2016 editorial staff for the MSRJ! We are beyond excited for the upcoming academic year as we welcome 20+ new junior editors to the experienced MSRJ staff. The journal has been making incredible progress and we look forward to another productive year publishing impressive article submissions and supporting medical student research around the world! (more…)